Calendula

• Wound Healing & Skin Repair
• Anti‑Inflammatory Activity
• Antimicrobial & Antifungal Effects
• Antioxidant & Photoprotective Effects
• Lymphatic & Circulatory Support
• GI & Gynecological Support

A bright, resinous, antioxidant‑rich Asteraceae herb renowned for wound healing, skin repair, inflammation modulation, and gentle lymphatic support.

• Family: Asteraceae
• Type: Annual or short‑lived perennial
• Height: 30–60 cm
• Leaves: Spatulate to oblong, slightly sticky, aromatic
• Flowers: Bright yellow to deep orange daisy‑like heads
• Origin: Mediterranean; now cultivated worldwide

Sources:
International Journal of Pharmaceutical Sciences review (2024)
IJPRA comprehensive review (2025)

Calendula is chemically dense, containing:
- Flavonoids

• Quercetin
• Isoquercetin
• Rutin
• Isorhamnetin
  - Triterpenoids & Triterpene Alcohols
• Oleanolic acid
• Stigmasterol
• Triterpeneol esters
  - Carotenoids
• Lutein
• Flavoxanthin
• Rubixanthin
• β‑carotene
• Lycopene
  - Other Constituents
• Saponins
• Coumarins
• Quinones (plastoquinone, phylloquinone, tocopherol, ubiquinone)
• Essential oils
• Amino acids (15 identified across plant parts)

Sources:

IJPS phytochemistry review (2024)
IJPRA review (2025)
Comprehensive medicinal review (2024)

1. Wound Healing & Skin Repair
   Calendula is one of the most researched topical herbs for:

• Cuts, scrapes, abrasions
• Burns
• Dermatitis
• Post‑surgical healing
• Radiation‑related skin irritation
  Mechanisms include:
• Increased collagen synthesis
• Enhanced epithelialization
• Antimicrobial protection

Sources:
IJPS review – wound healing, tissue repair, burn support
IJPRA review – skin injuries, mucosal healing

2. Anti‑Inflammatory Activity
   Calendula reduces inflammatory markers and inhibits lipoxygenase.
   Useful for:

• Skin inflammation
• GI irritation
• Oral inflammation
• Musculoskeletal swelling

• Sources:
  IJPS review – anti‑inflammatory & lipoxygenase inhibition
  IJPRA review – inflammation, ulcers, GI issues

3. Antimicrobial & Antifungal Effects
   Extracts show activity against:

• Staphylococcus aureus
• E. coli
• Candida albicans
• Aspergillus niger
• Methanol extracts often outperform ethanol extracts.

Sources:
IJPS review – antimicrobial spectrum
IJPRA review – antibacterial & antifungal activity

4. Antioxidant & Photoprotective Effects
   Calendula scavenges hydroxyl and superoxide radicals and protects lipids from peroxidation.

Sources:
IJPRA review – antioxidative activity in liposomal models
IJPS review – carotenoid‑driven antioxidant effects

5. Lymphatic & Circulatory Support
   Calendula promotes lymphatic flow and toxin clearance, making it useful for:

• Swelling
• Congestion
• Slow‑healing tissues

Source:
IJPS review – lymphatic circulation enhancement

6. GI & Gynecological Support
   Traditionally used for:

• Gastritis
• Ulcers
• Dysmenorrhea
• Uterine congestion

Sources:
IJPRA review – GI, gynecological, and mucosal uses
Medicinal review – internal uses for spasms, ulcers, mucosal inflammation